Assay Detail
Functional
CHEMBL5029587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.01 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468642 | — | — | 1 | 8.96 |
| CHEMBL5081479 | — | — | 1 | 8.85 |
| CHEMBL5091594 | — | — | 1 | 8.68 |
| CHEMBL5080238 | — | — | 1 | 8.60 |
| CHEMBL5077556 | — | — | 1 | 8.55 |
| CHEMBL5082999 | — | — | 1 | 8.49 |
| CHEMBL4473244 | — | — | 1 | 8.41 |
| CHEMBL5081488 | — | — | 1 | 8.40 |
| CHEMBL5074758 | — | — | 1 | 8.40 |
| CHEMBL5094651 | — | — | 1 | 8.38 |
| CHEMBL5075091 | — | — | 1 | 8.30 |
| CHEMBL5082677 | — | — | 1 | 8.26 |
| CHEMBL5092210 | — | — | 1 | 8.23 |
| CHEMBL5070361 | — | — | 1 | 8.17 |
| CHEMBL5089211 | — | — | 1 | 8.06 |
| CHEMBL5077444 | — | — | 1 | 8.01 |
| CHEMBL5078951 | — | — | 1 | 7.88 |
| CHEMBL5084532 | — | — | 1 | 7.85 |
| CHEMBL5078892 | — | — | 1 | 7.83 |
| CHEMBL5091955 | — | — | 1 | 7.71 |
| CHEMBL5093354 | — | — | 1 | 7.63 |
| CHEMBL5077762 | — | — | 1 | 7.55 |
| CHEMBL5092197 | — | — | 1 | 7.47 |
| CHEMBL5085733 | — | — | 1 | 7.29 |
| CHEMBL5088116 | — | — | 1 | 7.26 |
| CHEMBL5082985 | — | — | 1 | 7.17 |
| CHEMBL5092975 | — | — | 1 | 7.05 |
| CHEMBL5085706 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468642 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5081479 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5091594 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5080238 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5077556 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5082999 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4473244 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5081488 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5074758 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5094651 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5075091 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5082677 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5092210 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5070361 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5089211 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5077444 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL5078951 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5084532 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL5078892 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5091955 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL5093354 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL5077762 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL5092197 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL5085733 | — | IC50 | = | 51.5 | nM | 7.29 |
| CHEMBL5088116 | — | IC50 | = | 54.9 | nM | 7.26 |
| CHEMBL5082985 | — | IC50 | = | 68.1 | nM | 7.17 |
| CHEMBL5092975 | — | IC50 | = | 89.7 | nM | 7.05 |
| CHEMBL5085706 | — | IC50 | = | 139.3 | nM | 6.86 |