Assay Detail
Functional
CHEMBL5029589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.96 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081479 | — | — | 1 | 8.74 |
| CHEMBL4468642 | — | — | 1 | 8.70 |
| CHEMBL4473244 | — | — | 1 | 8.62 |
| CHEMBL5070361 | — | — | 1 | 8.60 |
| CHEMBL5094651 | — | — | 1 | 8.59 |
| CHEMBL5081488 | — | — | 1 | 8.52 |
| CHEMBL5082999 | — | — | 1 | 8.44 |
| CHEMBL5091594 | — | — | 1 | 8.43 |
| CHEMBL5080238 | — | — | 1 | 8.43 |
| CHEMBL5077444 | — | — | 1 | 8.37 |
| CHEMBL5092210 | — | — | 1 | 8.30 |
| CHEMBL5074758 | — | — | 1 | 8.23 |
| CHEMBL5077556 | — | — | 1 | 8.17 |
| CHEMBL5075091 | — | — | 1 | 8.10 |
| CHEMBL5082677 | — | — | 1 | 8.06 |
| CHEMBL5089211 | — | — | 1 | 7.82 |
| CHEMBL5078951 | — | — | 1 | 7.78 |
| CHEMBL5088116 | — | — | 1 | 7.68 |
| CHEMBL5085733 | — | — | 1 | 7.68 |
| CHEMBL5078892 | — | — | 1 | 7.65 |
| CHEMBL5091955 | — | — | 1 | 7.64 |
| CHEMBL5084532 | — | — | 1 | 7.44 |
| CHEMBL5093354 | — | — | 1 | 7.38 |
| CHEMBL5077762 | — | — | 1 | 7.28 |
| CHEMBL5092197 | — | — | 1 | 7.27 |
| CHEMBL5092975 | — | — | 1 | 7.09 |
| CHEMBL5082985 | — | — | 1 | 7.07 |
| CHEMBL5085706 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081479 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4468642 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4473244 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5070361 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5094651 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5081488 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5082999 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5091594 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5080238 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5077444 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5092210 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5074758 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5077556 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5075091 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5082677 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5089211 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL5078951 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL5088116 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL5085733 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL5078892 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL5091955 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL5084532 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL5093354 | — | IC50 | = | 41.2 | nM | 7.38 |
| CHEMBL5077762 | — | IC50 | = | 52.3 | nM | 7.28 |
| CHEMBL5092197 | — | IC50 | = | 53.8 | nM | 7.27 |
| CHEMBL5092975 | — | IC50 | = | 80.9 | nM | 7.09 |
| CHEMBL5082985 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5085706 | — | IC50 | = | 174.5 | nM | 6.76 |