Assay Detail
Binding
CHEMBL5029809
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Inhibition of BRD4 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.10 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091333 | — | — | 1 | 9.40 |
| CHEMBL5075294 | — | — | 1 | 9.30 |
| CHEMBL5089688 | — | — | 1 | 9.22 |
| CHEMBL5084198 | — | — | 1 | 9.22 |
| CHEMBL5090513 | — | — | 1 | 9.22 |
| CHEMBL5090808 | — | — | 1 | 9.15 |
| CHEMBL4297458 | EZOBRESIB | 2.0 | 1 | 9.10 |
| CHEMBL5086429 | — | — | 1 | 8.89 |
| CHEMBL5084636 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091333 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5075294 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5089688 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5084198 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5090513 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5090808 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4297458 | EZOBRESIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5086429 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5084636 | — | IC50 | = | 4.0 | nM | 8.40 |