Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5030076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthetic enamine naphthoquinone derived from lawsone as cytotoxic agents assessed by in vitro and in silico evaluations.
Lemos BC, Westphal R, Filho EV, Fiorot RG, Carneiro JWM, Gomes ACC, Guimarães CJ, de Oliveira FCE, Costa PMS, Pessoa C, Greco SJ.
Bioorg Med Chem Lett (2021) 53 : 128419 -128419
PubMed 34715305 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.72 5.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 5.69
CHEMBL2334466 1 5.34
CHEMBL1277345 1 5.32
CHEMBL5088346 1 4.56
CHEMBL5077570 1 4.52
CHEMBL240319 1 4.38
CHEMBL462058 1 4.30
CHEMBL5084635 1 4.27
CHEMBL2334461 1 4.06
CHEMBL165297 1 -
CHEMBL5092410 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 2050.0 nM 5.69
CHEMBL2334466 IC50 = 4590.0 nM 5.34
CHEMBL1277345 IC50 = 4780.0 nM 5.32
CHEMBL5088346 IC50 = 27480.0 nM 4.56
CHEMBL5077570 IC50 = 30000.0 nM 4.52
CHEMBL240319 IC50 = 41370.0 nM 4.38
CHEMBL462058 IC50 = 49810.0 nM 4.30
CHEMBL5084635 IC50 = 53410.0 nM 4.27
CHEMBL2334461 IC50 = 86450.0 nM 4.06
CHEMBL165297 IC50 = 111100.0 nM -
CHEMBL5092410 IC50 > 200000.0 nM -