Assay Detail
Functional
CHEMBL5030102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cell line assessed as cell growth inhibition
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.93 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5078868 | — | — | 1 | 8.00 |
| CHEMBL5071797 | — | — | 1 | 8.00 |
| CHEMBL5079415 | — | — | 1 | 7.70 |
| CHEMBL5074752 | — | — | 1 | 7.70 |
| CHEMBL5072429 | — | — | 1 | 7.70 |
| CHEMBL5081377 | — | — | 1 | 7.70 |
| CHEMBL5076249 | — | — | 1 | 7.70 |
| CHEMBL5073358 | — | — | 1 | 7.52 |
| CHEMBL5090451 | — | — | 1 | 7.52 |
| CHEMBL5089009 | — | — | 1 | 7.40 |
| CHEMBL5080892 | — | — | 1 | 7.40 |
| CHEMBL5086146 | — | — | 1 | 7.40 |
| CHEMBL5083727 | — | — | 1 | 7.40 |
| CHEMBL5076203 | — | — | 1 | 7.30 |
| CHEMBL5082062 | — | — | 1 | 7.16 |
| CHEMBL5078379 | — | — | 1 | 6.75 |
| CHEMBL5069458 | — | — | 1 | 6.75 |
| CHEMBL5073254 | — | — | 1 | 6.64 |
| CHEMBL5072779 | — | — | 1 | 6.62 |
| CHEMBL5087393 | — | — | 1 | 6.51 |
| CHEMBL5089201 | — | — | 1 | 6.48 |
| CHEMBL5079593 | — | — | 1 | 6.46 |
| CHEMBL5093023 | — | — | 1 | 6.41 |
| CHEMBL5093885 | — | — | 1 | 6.39 |
| CHEMBL5073703 | — | — | 1 | 6.39 |
| CHEMBL5091129 | — | — | 1 | 6.24 |
| CHEMBL5081649 | — | — | 1 | 6.24 |
| CHEMBL5093472 | — | — | 1 | 6.20 |
| CHEMBL458997 | — | — | 1 | 6.19 |
| CHEMBL5074601 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5078868 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5071797 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5074752 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5072429 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5081377 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5076249 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5079415 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5073358 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5090451 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5083727 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5086146 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5080892 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5089009 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5076203 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5082062 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5078379 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5069458 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5073254 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5072779 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5087393 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5089201 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5079593 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5093023 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5093885 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5073703 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5091129 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5081649 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5093472 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL458997 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5074601 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5085443 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5086430 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL5080758 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5079352 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5079756 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5073460 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5091653 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5077528 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5082883 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5089114 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5089411 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5078546 | — | IC50 | > | 5000.0 | nM | - |