Assay Detail
ADMET
CHEMBL5030107
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Cytotoxicity against mouse L929 cells assessed as cell growth inhibition
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.25 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5071797 | — | — | 1 | 6.72 |
| CHEMBL5074752 | — | — | 1 | 6.68 |
| CHEMBL5076249 | — | — | 1 | 6.64 |
| CHEMBL5089009 | — | — | 1 | 6.44 |
| CHEMBL5078868 | — | — | 1 | 5.62 |
| CHEMBL458997 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5071797 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5074752 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5076249 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5089009 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5078868 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL458997 | — | IC50 | = | 3990.0 | nM | 5.40 |