Assay Detail
Functional
CHEMBL5030898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A-375 cells harboring BRAF mutant assessed as reduction in cell viability incubated for 24 hrs by Click-iT EdU cell proliferation imaging assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.20 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094268 | — | — | 1 | 8.10 |
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 7.55 |
| CHEMBL5090624 | — | — | 1 | 7.32 |
| CHEMBL5079215 | — | — | 1 | 7.07 |
| CHEMBL5094514 | — | — | 1 | 7.03 |
| CHEMBL4780060 | — | — | 1 | 6.95 |
| CHEMBL5075174 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094268 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3577124 | LY-3009120 | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL5090624 | — | IC50 | = | 47.4 | nM | 7.32 |
| CHEMBL5079215 | — | IC50 | = | 85.3 | nM | 7.07 |
| CHEMBL5094514 | — | IC50 | = | 92.6 | nM | 7.03 |
| CHEMBL4780060 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5075174 | — | IC50 | = | 405.0 | nM | 6.39 |