Assay Detail
Functional
CHEMBL5031191
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Anti-HIV-1 activity against HIV1 BaL (subtype B, R5) assessed as inhibition of infection in human CEMx174 5.25M7 cells expressing CCR5/CXCR4 by measuring P24 antigen after 6 days by ELISA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEMx174 5.25M7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
A "Two-Birds-One-Stone" Approach toward the Design of Bifunctional Human Immunodeficiency Virus Type 1 Entry Inhibitors Targeting the CCR5 Coreceptor and gp41 N-Terminal Heptad Repeat Region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 9.12 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5078769 | — | — | 1 | 10.52 |
| CHEMBL5084630 | — | — | 1 | 9.60 |
| CHEMBL5085173 | — | — | 1 | 9.31 |
| CHEMBL5077714 | — | — | 1 | 9.20 |
| CHEMBL5082815 | — | — | 1 | 9.05 |
| CHEMBL2380932 | — | — | 1 | 8.92 |
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 8.80 |
| CHEMBL5075904 | — | — | 1 | 8.68 |
| CHEMBL5084989 | — | — | 1 | 8.04 |
| CHEMBL5086575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5078769 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL5084630 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5085173 | — | EC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5077714 | — | EC50 | = | 0.63 | nM | 9.20 |
| CHEMBL5082815 | — | EC50 | = | 0.89 | nM | 9.05 |
| CHEMBL2380932 | — | EC50 | = | 1.19 | nM | 8.92 |
| CHEMBL525076 | ENFUVIRTIDE | EC50 | = | 1.58 | nM | 8.80 |
| CHEMBL5075904 | — | EC50 | = | 2.08 | nM | 8.68 |
| CHEMBL5084989 | — | EC50 | = | 9.18 | nM | 8.04 |
| CHEMBL5086575 | — | EC50 | > | 50.0 | nM | - |