Assay Detail
Binding
CHEMBL5031741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Haloperidol Metabolite II Valproate Ester (<i>S</i>)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.19 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129159 | — | — | 1 | 8.70 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.66 |
| CHEMBL1036 | HYDROXYHALOPERIDOL | — | 1 | 8.54 |
| CHEMBL129237 | — | — | 1 | 8.52 |
| CHEMBL4747257 | — | — | 1 | 7.89 |
| CHEMBL5079556 | — | — | 1 | 7.80 |
| CHEMBL5094340 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129159 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1036 | HYDROXYHALOPERIDOL | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL129237 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4747257 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5079556 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL5094340 | — | Ki | = | 64.0 | nM | 7.19 |