Assay Detail
Binding
CHEMBL5032402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins by RapidFire Mass spectrometry assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hypoxia-inducible factor 1-alpha inhibitor (CHEMBL5909) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.75 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091848 | — | — | 1 | 5.40 |
| CHEMBL5072902 | — | — | 1 | 5.11 |
| CHEMBL5071002 | — | — | 1 | 4.98 |
| CHEMBL5089117 | — | — | 1 | 4.82 |
| CHEMBL5083418 | — | — | 1 | 4.80 |
| CHEMBL5089880 | — | — | 1 | 4.72 |
| CHEMBL5081435 | — | — | 1 | 4.71 |
| CHEMBL5076580 | — | — | 1 | 4.70 |
| CHEMBL5084638 | — | — | 1 | 4.62 |
| CHEMBL5070745 | — | — | 1 | 4.53 |
| CHEMBL5071515 | — | — | 1 | 4.52 |
| CHEMBL5084143 | — | — | 1 | 4.06 |
| CHEMBL5080728 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091848 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5072902 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5071002 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5089117 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL5083418 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL5089880 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL5081435 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL5076580 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL5084638 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL5070745 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL5071515 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL5084143 | — | IC50 | = | 86600.0 | nM | 4.06 |
| CHEMBL5080728 | — | IC50 | > | 100000.0 | nM | - |