Hypoxia-inducible factor 1-alpha inhibitor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9NWT6. Use UniProt Q9NWT6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NWT6 as the stable identity anchor, then attach disease evidence before program review.
Hypoxia-inducible factor 1-alpha inhibitor
Review this target as Hypoxia-inducible factor 1-alpha inhibitor, mapped to UniProt Q9NWT6. Sequence length is 349 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hypoxia-inducible factor 1-alpha inhibitor as ChEMBL target CHEMBL5909, mapped to UniProt Q9NWT6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Hypoxia-inducible factor 1-alpha inhibitor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NWT6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hypoxia-inducible factor 1-alpha inhibitor |
| UniProt Accession | Q9NWT6 |
| Component Type | Protein |
| Sequence Length | 349 aa |
Hypoxia-inducible factor 1-alpha inhibitor
Review this target as Hypoxia-inducible factor 1-alpha inhibitor, mapped to UniProt Q9NWT6. Sequence length is 349 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL316034 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL5404184 | 5.62 | IC50 | 2380.0 | Preclinical |
| CHEMBL5418688 | 5.62 | IC50 | 2380.0 | Preclinical |
| CHEMBL5410721 | 5.53 | IC50 | 2970.0 | Preclinical |
| CHEMBL5410158 | 5.48 | IC50 | 3310.0 | Preclinical |
| CHEMBL5426884 | 5.44 | IC50 | 3600.0 | Preclinical |
| CHEMBL5436718 | 5.44 | IC50 | 3600.0 | Preclinical |
| CHEMBL5437483 | 5.42 | IC50 | 3780.0 | Preclinical |
| CHEMBL5091848 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL5421814 | 5.4 | IC50 | 3990.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 14 | 42 | 4.6 |
| assay format | 3 | 4 | 4.2 |
| cell-based format | 2 | 25 | 5.3 |