Compound Detail
CHEMBL5404184
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Basic Information
| ChEMBL ID | CHEMBL5404184 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LSADYJMTVGUMNS-RMKNXTFCSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
449.6
MW (Da)
4.96
ALogP
6
HBA
1
HBD
68.2
PSA (Ų)
0.45
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hypoxia-inducible factor 1-alpha inhibitor CHEMBL5909 | IC50 | 5.62 | 5.62 | 2380.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hypoxia-inducible factor 1-alpha inhibitor | IC50 | = | 2380.0 | nM | 5.62 | Inhibition of HIF-1 alpha transcriptional activity in human U-251 cells incubate... | 36774697 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36774697 | 10.1016/j.ejmech.2023.115171 | Hypoxia-inducible factor 1-alpha inhibitor | 1 |
Data from ChEMBL 36 via Core Engine