Assay Detail
Functional
CHEMBL5032826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-viral activity against Enterovirus A71 Tainan/4643/1998 infected in human RD cells assessed as reduction in virus induced cytopathic effect incubated for 3 days by CPE assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterovirus A71 |
| Cell Type | RD |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.21 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5078536 | — | — | 1 | 7.40 |
| CHEMBL5074046 | — | — | 1 | 7.00 |
| CHEMBL5079166 | — | — | 1 | 7.00 |
| CHEMBL5088460 | — | — | 1 | 7.00 |
| CHEMBL5094591 | — | — | 1 | 7.00 |
| CHEMBL5084975 | — | — | 1 | 7.00 |
| CHEMBL5088726 | — | — | 1 | 7.00 |
| CHEMBL5094626 | — | — | 1 | 7.00 |
| CHEMBL5094096 | — | — | 1 | 6.70 |
| CHEMBL5085721 | — | — | 1 | 6.70 |
| CHEMBL5084599 | — | — | 1 | 6.70 |
| CHEMBL5093400 | — | — | 1 | 6.70 |
| CHEMBL5086660 | — | — | 1 | 6.52 |
| CHEMBL5081053 | — | — | 1 | 6.40 |
| CHEMBL5079327 | — | — | 1 | 6.30 |
| CHEMBL5074802 | — | — | 1 | 6.30 |
| CHEMBL5093853 | — | — | 1 | 6.30 |
| CHEMBL5075708 | — | — | 1 | 6.22 |
| CHEMBL5081168 | — | — | 1 | 6.22 |
| CHEMBL5075647 | — | — | 1 | 6.16 |
| CHEMBL5088724 | — | — | 1 | 6.00 |
| CHEMBL5081129 | — | — | 1 | 5.75 |
| CHEMBL5079052 | — | — | 1 | 5.70 |
| CHEMBL5084010 | — | — | 1 | 5.46 |
| CHEMBL5088253 | — | — | 1 | 5.28 |
| CHEMBL5091724 | — | — | 1 | 5.21 |
| CHEMBL5081706 | — | — | 1 | 5.14 |
| CHEMBL5075415 | — | — | 1 | 5.13 |
| CHEMBL5089892 | — | — | 1 | 5.09 |
| CHEMBL5094881 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5078536 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5074046 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5079166 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5088460 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5094591 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5084975 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5088726 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5094626 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5094096 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5085721 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5084599 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5093400 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5086660 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5081053 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5074802 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5093853 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5079327 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5075708 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5081168 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5075647 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5088724 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5081129 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5079052 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5084010 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5088253 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5091724 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5081706 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5075415 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5089892 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5094881 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5085787 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5088301 | — | EC50 | > | 20000.0 | nM | - |