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Assay Detail

CHEMBL5032883

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Induction of disruption of r(CCUG)12-MBNL1 complex (unknown origin) incubated for 15 mins by TR-FRET assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways.
Wagner-Griffin S, Abe M, Benhamou RI, Angelbello AJ, Vishnu K, Chen JL, Childs-Disney JL, Disney MD.
J Med Chem (2021) 64 : 8474 -8485
PubMed 34101465 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 82 4.63 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5087124 1 6.70
CHEMBL5078834 1 6.52
CHEMBL5089176 1 6.52
CHEMBL5092071 1 6.40
CHEMBL5075325 1 6.00
CHEMBL5079565 1 6.00
CHEMBL5085783 1 5.70
CHEMBL5090835 1 5.40
CHEMBL5093033 1 5.16
CHEMBL5079182 1 5.00
CHEMBL5086011 1 5.00
CHEMBL5085100 1 5.00
CHEMBL5087841 1 5.00
CHEMBL5094054 1 4.82
CHEMBL5088202 1 4.70
CHEMBL5083599 1 4.70
CHEMBL5078110 1 4.52
CHEMBL5088264 1 4.52
CHEMBL5085754 1 4.52
CHEMBL5077669 1 4.46
CHEMBL3808617 1 4.40
CHEMBL5094908 1 4.40
CHEMBL4082535 1 4.35
CHEMBL5086427 1 4.30
CHEMBL5083630 1 4.30
CHEMBL5070611 1 4.30
CHEMBL5092427 1 4.22
CHEMBL5080960 1 4.22
CHEMBL5087804 1 4.22
CHEMBL5093361 1 4.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5087124 IC50 = 200.0 nM 6.70
CHEMBL5078834 IC50 = 300.0 nM 6.52
CHEMBL5089176 IC50 = 300.0 nM 6.52
CHEMBL5092071 IC50 = 400.0 nM 6.40
CHEMBL5075325 IC50 = 1000.0 nM 6.00
CHEMBL5079565 IC50 = 1000.0 nM 6.00
CHEMBL5085783 IC50 = 2000.0 nM 5.70
CHEMBL5090835 IC50 = 4000.0 nM 5.40
CHEMBL5093033 IC50 = 7000.0 nM 5.16
CHEMBL5079182 IC50 = 10000.0 nM 5.00
CHEMBL5086011 IC50 = 10000.0 nM 5.00
CHEMBL5085100 IC50 = 10000.0 nM 5.00
CHEMBL5087841 IC50 = 10000.0 nM 5.00
CHEMBL5094054 IC50 = 15000.0 nM 4.82
CHEMBL5083599 IC50 = 20000.0 nM 4.70
CHEMBL5088202 IC50 = 20000.0 nM 4.70
CHEMBL5078110 IC50 = 30000.0 nM 4.52
CHEMBL5088264 IC50 = 30000.0 nM 4.52
CHEMBL5085754 IC50 = 30000.0 nM 4.52
CHEMBL5077669 IC50 = 35000.0 nM 4.46
CHEMBL3808617 IC50 = 40000.0 nM 4.40
CHEMBL5094908 IC50 = 40000.0 nM 4.40
CHEMBL4082535 IC50 = 45000.0 nM 4.35
CHEMBL5070611 IC50 = 50000.0 nM 4.30
CHEMBL5086427 IC50 = 50000.0 nM 4.30
CHEMBL5083630 IC50 = 50000.0 nM 4.30
CHEMBL5092427 IC50 = 60000.0 nM 4.22
CHEMBL5080960 IC50 = 60000.0 nM 4.22
CHEMBL5087804 IC50 = 60000.0 nM 4.22
CHEMBL5093361 IC50 = 65000.0 nM 4.19
CHEMBL5094335 IC50 = 70000.0 nM 4.16
CHEMBL5083215 IC50 = 70000.0 nM 4.16
CHEMBL5087066 IC50 = 70000.0 nM 4.16
CHEMBL5077362 IC50 = 70000.0 nM 4.16
CHEMBL5076423 IC50 = 70000.0 nM 4.16
CHEMBL5088344 IC50 = 70000.0 nM 4.16
CHEMBL5093070 IC50 = 75000.0 nM 4.12
CHEMBL5092670 IC50 = 75000.0 nM 4.12
CHEMBL5075311 IC50 = 80000.0 nM 4.10
CHEMBL5089460 IC50 = 80000.0 nM 4.10
CHEMBL527587 IC50 = 80000.0 nM 4.10
CHEMBL5094946 IC50 = 85000.0 nM 4.07
CHEMBL5093819 IC50 = 85000.0 nM 4.07
CHEMBL5094434 IC50 = 90000.0 nM 4.05
CHEMBL5083698 IC50 = 90000.0 nM 4.05
CHEMBL5094375 IC50 = 95000.0 nM 4.02
CHEMBL5079615 IC50 = 95000.0 nM 4.02
CHEMBL5079447 IC50 = 100000.0 nM 4.00
CHEMBL5087836 IC50 = 100000.0 nM 4.00
CHEMBL5079164 IC50 = 100000.0 nM 4.00