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Compound Detail

CHEMBL5085754

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CCNc1nc(Nc2ccc(NC(C)=O)cc2)nc2ccccc12

Basic Information

ChEMBL ID CHEMBL5085754
Phase Preclinical
Structure Type MOL
InChI Key WDWOTSNCCOYPDF-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

321.4
MW (Da)
3.76
ALogP
5
HBA
3
HBD
78.9
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H19N5O
MW 321.38
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness -1.51

Activity Summary

IC50 1 meas. best 4.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.52 4.52 30000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 30000.0 nM 4.52 Induction of disruption of r(CCUG)12-MBNL1 complex (unknown origin) incubated fo... 34101465

Literature References

PubMed DOI Target Context # Activities
34101465 10.1021/acs.jmedchem.1c00414 Unchecked 2

Data from ChEMBL 36 via Core Engine