Assay Detail
Binding
CHEMBL5032958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PD-1/PD-L1 interaction assessed as blockade activity incubated for 15 mins by HTRF assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[<i>c</i>][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with <i>In Vivo</i> Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.27 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5092744 | — | — | 1 | 8.74 |
| CHEMBL5081629 | — | — | 1 | 8.59 |
| CHEMBL5086579 | — | — | 1 | 8.48 |
| CHEMBL5081208 | — | — | 1 | 8.46 |
| CHEMBL5089213 | — | — | 1 | 8.19 |
| CHEMBL5093300 | — | — | 1 | 8.11 |
| CHEMBL5082639 | — | — | 1 | 8.11 |
| CHEMBL5077123 | — | — | 1 | 8.09 |
| CHEMBL5069508 | — | — | 1 | 8.02 |
| CHEMBL5094163 | — | — | 1 | 7.88 |
| CHEMBL5091570 | — | — | 1 | 7.84 |
| CHEMBL5076462 | — | — | 1 | 7.80 |
| CHEMBL5092891 | — | — | 1 | 7.78 |
| CHEMBL5079158 | — | — | 1 | 7.67 |
| CHEMBL5075064 | — | — | 1 | 7.61 |
| CHEMBL5087916 | — | — | 1 | 7.61 |
| CHEMBL5084706 | — | — | 1 | 7.57 |
| CHEMBL5088657 | — | — | 1 | 7.56 |
| CHEMBL5087535 | — | — | 1 | 7.51 |
| CHEMBL5081726 | — | — | 1 | 7.51 |
| CHEMBL5090292 | — | — | 1 | 7.47 |
| CHEMBL5092191 | — | — | 1 | 7.47 |
| CHEMBL5087877 | — | — | 1 | 7.45 |
| CHEMBL5079880 | — | — | 1 | 7.28 |
| CHEMBL5075291 | — | — | 1 | 7.25 |
| CHEMBL5071084 | — | — | 1 | 7.24 |
| CHEMBL5090380 | — | — | 1 | 7.23 |
| CHEMBL5092015 | — | — | 1 | 7.21 |
| CHEMBL5084021 | — | — | 1 | 6.99 |
| CHEMBL5084057 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5092744 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5081629 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5086579 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5081208 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5089213 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5093300 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5082639 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5077123 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5069508 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL5094163 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL5091570 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL5076462 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL5092891 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5079158 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL5087916 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL5075064 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL5084706 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL5088657 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL5087535 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL5081726 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL5092191 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL5090292 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL5087877 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL5079880 | — | IC50 | = | 52.3 | nM | 7.28 |
| CHEMBL5075291 | — | IC50 | = | 56.1 | nM | 7.25 |
| CHEMBL5071084 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL5090380 | — | IC50 | = | 58.7 | nM | 7.23 |
| CHEMBL5092015 | — | IC50 | = | 60.9 | nM | 7.21 |
| CHEMBL5084021 | — | IC50 | = | 101.4 | nM | 6.99 |
| CHEMBL5084057 | — | IC50 | = | 129.8 | nM | 6.89 |
| CHEMBL5093484 | — | IC50 | = | 162.1 | nM | 6.79 |
| CHEMBL5086179 | — | IC50 | = | 205.6 | nM | 6.69 |
| CHEMBL5075170 | — | IC50 | = | 290.9 | nM | 6.54 |
| CHEMBL5077414 | — | IC50 | = | 341.7 | nM | 6.47 |
| CHEMBL5093718 | — | IC50 | = | 392.9 | nM | 6.41 |
| CHEMBL5093287 | — | IC50 | = | 425.9 | nM | 6.37 |
| CHEMBL5082398 | — | IC50 | = | 1054.5 | nM | 5.98 |
| CHEMBL5085728 | — | IC50 | = | 1384.5 | nM | 5.86 |
| CHEMBL5088893 | — | IC50 | = | 1580.5 | nM | 5.80 |
| CHEMBL5084418 | — | IC50 | = | 2159.5 | nM | 5.67 |
| CHEMBL5089057 | — | IC50 | = | 2343.5 | nM | 5.63 |
| CHEMBL5080903 | — | IC50 | = | 3592.5 | nM | 5.45 |
| CHEMBL5083609 | — | IC50 | > | 1000.0 | nM | - |