Assay Detail
Functional
CHEMBL5033065
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Antiproliferative activity against human SNU-16 cells expressing FGFR2 assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Optimization of a Novel 2<i>H</i>-Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.28 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3701238 | FUTIBATINIB | 4.0 | 1 | 8.40 |
| CHEMBL5088737 | — | — | 1 | 8.22 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3701238 | FUTIBATINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5088737 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 6.0 | nM | 8.22 |