Assay Detail
Binding
CHEMBL5033455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG expressed in CHO cells by whole cell patch clamp assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ<sub>1</sub> Receptor Antagonists for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.46 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094899 | — | — | 1 | 5.92 |
| CHEMBL5083271 | — | — | 1 | 5.66 |
| CHEMBL5092587 | — | — | 1 | 5.64 |
| CHEMBL5070613 | — | — | 1 | 5.64 |
| CHEMBL5075502 | — | — | 1 | 5.58 |
| CHEMBL5080086 | — | — | 1 | 5.54 |
| CHEMBL5090595 | — | — | 1 | 5.50 |
| CHEMBL5080761 | — | — | 1 | 5.47 |
| CHEMBL5074927 | — | — | 1 | 5.47 |
| CHEMBL5081133 | — | — | 1 | 5.46 |
| CHEMBL5089000 | — | — | 1 | 5.44 |
| CHEMBL5089365 | — | — | 1 | 5.32 |
| CHEMBL5084344 | — | — | 1 | 5.17 |
| CHEMBL5084395 | — | — | 1 | 5.06 |
| CHEMBL5087458 | — | — | 1 | 5.02 |
| CHEMBL5079310 | — | — | 1 | - |
| CHEMBL5091094 | — | — | 1 | - |
| CHEMBL5089489 | — | — | 1 | - |
| CHEMBL5090993 | — | — | 1 | - |
| CHEMBL5089766 | — | — | 1 | - |
| CHEMBL5086571 | — | — | 1 | - |
| CHEMBL5093051 | — | — | 1 | - |
| CHEMBL5085771 | — | — | 1 | - |
| CHEMBL5082031 | — | — | 1 | - |
| CHEMBL5081183 | — | — | 1 | - |
| CHEMBL5083736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094899 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5083271 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5092587 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5070613 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5075502 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5080086 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5090595 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5080761 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5074927 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5081133 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5089000 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5089365 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5084344 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5084395 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5087458 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5079310 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091094 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5089489 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5090993 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5089766 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5086571 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5093051 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5085771 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5082031 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5081183 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5083736 | — | IC50 | > | 10000.0 | nM | - |