Compound Detail
CHEMBL5093051
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Basic Information
| ChEMBL ID | CHEMBL5093051 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWJSAJQGUZTVMZ-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
442.5
MW (Da)
3.42
ALogP
5
HBA
0
HBD
48.9
PSA (Ų)
0.65
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.66
EC50 1 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL233 | EC50 | 6.75 | 6.75 | 180.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 6.66 | 6.66 | 220.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 6.64 | 6.64 | 231.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 9.4 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | EC50 | = | 180.0 | nM | 6.75 | Agonist activity at human MOR expressed in CHO-K1 cells assessed as reduction in... | 34236190 |
| Mu-type opioid receptor | Ki | = | 220.0 | nM | 6.66 | Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes inc... | 34236190 |
| Sigma non-opioid intracellular receptor 1 | Ki | = | 231.0 | nM | 6.64 | Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor transfected in ... | 34236190 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34236190 | 10.1021/acs.jmedchem.1c00417 | Mu-type opioid receptor | 3 |
| 34236190 | 10.1021/acs.jmedchem.1c00417 | Sigma non-opioid intracellular receptor 1 | 1 |
| 34236190 | 10.1021/acs.jmedchem.1c00417 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 34236190 | 10.1021/acs.jmedchem.1c00417 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine