Assay Detail
Binding
CHEMBL5033501
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Binding affinity to Grb2-SH2 domain (unknown origin) by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.91 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1205233 | — | — | 1 | 8.37 |
| CHEMBL291678 | — | — | 1 | 7.70 |
| CHEMBL303150 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1205233 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL291678 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL303150 | — | IC50 | = | 22.0 | nM | 7.66 |