Assay Detail
Binding
CHEMBL5034535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4B2 assessed as reduction in cAMP level incubated for 2 hrs by LANCE Ultra cAMP TR-FRET assay
34
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of M<sub>3</sub> Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 8.84 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5077250 | — | — | 1 | 9.50 |
| CHEMBL5086393 | — | — | 2 | 9.30 |
| CHEMBL5091461 | — | — | 1 | 9.30 |
| CHEMBL5081816 | — | — | 2 | 9.20 |
| CHEMBL5076535 | — | — | 2 | 9.20 |
| CHEMBL5085166 | — | — | 1 | 9.20 |
| CHEMBL5086272 | — | — | 1 | 9.20 |
| CHEMBL5076637 | — | — | 2 | 9.20 |
| CHEMBL5086769 | — | — | 1 | 9.10 |
| CHEMBL5076886 | — | — | 2 | 9.00 |
| CHEMBL5084383 | — | — | 1 | 9.00 |
| CHEMBL5070876 | — | — | 1 | 9.00 |
| CHEMBL5076445 | — | — | 2 | 8.90 |
| CHEMBL5074599 | — | — | 2 | 8.80 |
| CHEMBL5074216 | — | — | 2 | 8.80 |
| CHEMBL5078006 | — | — | 2 | 8.80 |
| CHEMBL5077424 | — | — | 2 | 8.70 |
| CHEMBL5077161 | — | — | 1 | 8.70 |
| CHEMBL5075132 | — | — | 1 | 8.60 |
| CHEMBL5076558 | — | — | 2 | 8.40 |
| CHEMBL5088742 | — | — | 1 | 8.20 |
| CHEMBL5076266 | — | — | 1 | 8.10 |
| CHEMBL5076680 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5077250 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL5086393 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL5091461 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL5081816 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5076637 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5076637 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5086272 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5085166 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5076535 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5086769 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5081816 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5084383 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5070876 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5076535 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5086393 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5076886 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5076886 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5076445 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL5074599 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5074599 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5074216 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5078006 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5077424 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5078006 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5077161 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5075132 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL5076445 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL5077424 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5074216 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5076558 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL5088742 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL5076558 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5076266 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5076680 | — | IC50 | = | 10.0 | nM | 8.00 |