Assay Detail
Functional
CHEMBL5034992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human RS4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
90
Total Activities
90
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RS4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of 3-Phenyl-<i>N</i>-(2-(3-phenylureido)ethyl)thiophene-2-sulfonamide Derivatives as Selective Mcl-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 90 | 5.25 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 8.37 |
| CHEMBL5086831 | — | — | 1 | 5.89 |
| CHEMBL5076103 | — | — | 1 | 5.85 |
| CHEMBL5088778 | — | — | 1 | 5.82 |
| CHEMBL5084489 | — | — | 1 | 5.68 |
| CHEMBL5075181 | — | — | 1 | 5.62 |
| CHEMBL5084869 | — | — | 1 | 5.52 |
| CHEMBL5070694 | — | — | 1 | 5.52 |
| CHEMBL5088326 | — | — | 1 | 5.48 |
| CHEMBL5083884 | — | — | 1 | 5.44 |
| CHEMBL5092439 | — | — | 1 | 5.43 |
| CHEMBL5080325 | — | — | 1 | 5.41 |
| CHEMBL5089059 | — | — | 1 | 5.39 |
| CHEMBL5078508 | — | — | 1 | 5.35 |
| CHEMBL5079843 | — | — | 1 | 5.35 |
| CHEMBL5091077 | — | — | 1 | 5.32 |
| CHEMBL5076953 | — | — | 1 | 5.32 |
| CHEMBL5079372 | — | — | 1 | 5.31 |
| CHEMBL5090868 | — | — | 1 | 5.31 |
| CHEMBL5083051 | — | — | 1 | 5.29 |
| CHEMBL5092026 | — | — | 1 | 5.29 |
| CHEMBL5088505 | — | — | 1 | 5.29 |
| CHEMBL5086162 | — | — | 1 | 5.26 |
| CHEMBL5077322 | — | — | 1 | 5.25 |
| CHEMBL5086959 | — | — | 1 | 5.25 |
| CHEMBL5094192 | — | — | 1 | 5.24 |
| CHEMBL5094114 | — | — | 1 | 5.24 |
| CHEMBL5085725 | — | — | 1 | 5.24 |
| CHEMBL5084152 | — | — | 1 | 5.21 |
| CHEMBL5089281 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5086831 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5076103 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5088778 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5084489 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5075181 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5084869 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5070694 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5088326 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5083884 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5092439 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5080325 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5089059 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5078508 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5079843 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5091077 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5076953 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5079372 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5090868 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5083051 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5092026 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5088505 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5086162 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5077322 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5086959 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5094192 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5085725 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5094114 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5084152 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5089281 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5086607 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5085546 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5072266 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5072573 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5094724 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5089773 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5090548 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3417704 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL5092837 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5084852 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5083087 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5081541 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5089455 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5091453 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5086500 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5080935 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5086300 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5085660 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5083775 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5077284 | — | IC50 | = | 9500.0 | nM | 5.02 |