Assay Detail
Functional
CHEMBL5035048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Enterovirus A71 H08300461-812 infected in human RD cells assessed as reduction in virus induced cytopathic effect incubated for 3 days by MTS/PMS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterovirus A71 |
| Cell Type | RD |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors†.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.58 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538215 | — | — | 1 | 8.59 |
| CHEMBL4451994 | — | — | 1 | 7.24 |
| CHEMBL5075004 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538215 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4451994 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5075004 | — | EC50 | = | 120.0 | nM | 6.92 |