Assay Detail
ADMET
CHEMBL5035201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C19 in human pooled liver microsomes using S-mephenytoin as substrate in presence of NADPH by LC-MS/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.48 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 4.91 |
| CHEMBL5080010 | — | — | 1 | 4.05 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL5080010 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | > | 50000.0 | nM | - |