Assay Detail
Functional
CHEMBL5035304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse BaF3 cells transfected with TrKA G595R mutant assessed as reduction in cell viability by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.45 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093999 | — | — | 1 | 9.40 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 8.17 |
| CHEMBL5080010 | — | — | 1 | 8.11 |
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093999 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5080010 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 8.0 | nM | 8.10 |