Assay Detail
Functional
CHEMBL5035308
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Cytotoxicity against mouse BaF3 cells transfected with SLC34A2-Ros1 assessed as reduction in cell viability by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.16 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 8.66 |
| CHEMBL5080010 | — | — | 1 | 8.64 |
| CHEMBL5093999 | — | — | 1 | 7.90 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5080010 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5093999 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 36.7 | nM | 7.43 |