Assay Detail
Binding
CHEMBL5035502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of isoQC (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminyl-peptide cyclotransferase-like protein (CHEMBL3638349) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.20 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089539 | — | — | 1 | 7.73 |
| CHEMBL5081502 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089539 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL5081502 | — | IC50 | = | 213.0 | nM | 6.67 |