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Target Snapshot

CHEMBL3638349 Target Snapshot

Glutaminyl-peptide cyclotransferase-like protein · SINGLE PROTEIN · Homo sapiens

132Compounds
12Assays
0Approved Drugs
173.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9NXS2. Use UniProt Q9NXS2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9NXS2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutaminyl-peptide cyclotransferase-like protein as ChEMBL target CHEMBL3638349, mapped to UniProt Q9NXS2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutaminyl-peptide cyclotransferase-like protein
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3638349
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9NXS2
Glutaminyl-peptide cyclotransferase-like protein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutaminyl-peptide cyclotransferase-like protein is the right protein anchor across sources, using UniProt Q9NXS2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutaminyl-peptide cyclotransferase-like protein
UniProt AccessionQ9NXS2
Component TypeProtein
Sequence Length382 aa

Glutaminyl-peptide cyclotransferase-like protein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glutaminyl-peptide cyclotransferase-like protein, mapped to UniProt Q9NXS2. Sequence length is 382 aa.

Mapped IDQ9NXS2
Review nameGlutaminyl-peptide cyclotransferase-like protein
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC50132.0
KI40.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5653589 8.24 Kd 5.799 Preclinical
CHEMBL2418779 8.0 Ki 10.0 Preclinical
CHEMBL3659477 8.0 IC50 10.0 Clinical
CHEMBL3649507 7.96 Ki 11.0 Preclinical
CHEMBL4462495 7.89 IC50 13.0 Preclinical
CHEMBL5089539 7.73 IC50 18.6 Preclinical
CHEMBL5555409 7.57 IC50 27.0 Preclinical
CHEMBL5561959 7.5 IC50 32.0 Preclinical
CHEMBL3649517 7.47 Ki 34.0 Preclinical
CHEMBL3914603 7.4 Ki 40.0 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
12
5.5
53
6.0
36
6.5
32
7.0
5
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
126
Tested Compounds
1
Assay Types
Binding — 12 assays, 126 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 11 75 6.6
assay format 1 51 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine