Assay Detail
Binding
CHEMBL5036223
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Modulation of CD33 pre-mRNA splicing in human K562 cells assessed as induction of exon 2 skipping measured after 18 to 24 hrs by Nano-Luciferase reporter assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.50 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4130157 | — | — | 1 | 6.24 |
| CHEMBL4114159 | — | — | 1 | 5.85 |
| CHEMBL4108330 | — | — | 1 | 5.44 |
| CHEMBL4107804 | — | — | 1 | 5.43 |
| CHEMBL4126496 | — | — | 1 | 5.36 |
| CHEMBL4109308 | — | — | 1 | 5.35 |
| CHEMBL4126072 | — | — | 1 | 5.25 |
| CHEMBL5088467 | — | — | 1 | 5.11 |
| CHEMBL4127458 | — | — | 1 | - |
| CHEMBL4127311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4130157 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4114159 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4108330 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4107804 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4126496 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4109308 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4126072 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5088467 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4127458 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4127311 | — | EC50 | > | 10000.0 | nM | - |