Compound Detail
CHEMBL4130157
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Basic Information
| ChEMBL ID | CHEMBL4130157 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CZOPBHFGGXCMCI-JOCHJYFZSA-N |
5
Targets
6
Activities
3
Assay Types
2
PK Parameters
7
Publications
0
Known Names
Molecular Properties
448.5
MW (Da)
4.34
ALogP
6
HBA
1
HBD
75.4
PSA (Ų)
0.44
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.16
EC50 1 meas. best 6.24
Ki 1 meas. best 5.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 6.24 | 6.24 | 580.0 | 1 |
| 80S Ribosome CHEMBL3987582 | IC50 | 6.16 | 6.025 | 690.0 | 2 |
| Proprotein convertase subtilisin/kexin type 9 CHEMBL2929 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Bone marrow cell CHEMBL4296515 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | Ki | 5.27 | 5.27 | 5400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 31.2 | mL.min-1.g-1 | Rattus norvegicus |
| CL | 14.5 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 580.0 | nM | 6.24 | Modulation of CD33 pre-mRNA splicing in human K562 cells assessed as induction o... | 35059124 |
| 80S Ribosome | IC50 | = | 690.0 | nM | 6.16 | Binding affinity to 80S ribosome in human HuH7 cells harboring pCMV-truncated hu... | 29878763 |
| 80S Ribosome | IC50 | = | 1290.0 | nM | 5.89 | Binding affinity to 80S ribosome in human HuH7 cells assessed as inhibition of P... | 29878763 |
| Proprotein convertase subtilisin/kexin type 9 | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assay | 35059124 |
| Bone marrow cell | IC50 | = | 1400.0 | nM | 5.85 | Cytotoxicity against rat bone marrow cells assessed as reduction in cell viabili... | 29878763 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | Ki | = | 5400.0 | nM | 5.27 | Inhibition of dofetilide binding to human ERG by fluorescence polarization assay | 29878763 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35059124 | 10.1021/acsmedchemlett.1c00396 | Unchecked | 3 |
| 29878763 | 10.1021/acs.jmedchem.8b00650 | ADMET | 2 |
| 29878763 | 10.1021/acs.jmedchem.8b00650 | 80S Ribosome | 2 |
| 29878763 | 10.1021/acs.jmedchem.8b00650 | No relevant target | 1 |
| 29878763 | 10.1021/acs.jmedchem.8b00650 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 29878763 | 10.1021/acs.jmedchem.8b00650 | Bone marrow cell | 1 |
| 35059124 | 10.1021/acsmedchemlett.1c00396 | Proprotein convertase subtilisin/kexin type 9 | 1 |
Data from ChEMBL 36 via Core Engine