Assay Detail
ADMET
CHEMBL4124699
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Cytotoxicity against rat bone marrow cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | Bone marrow cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.27 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126496 | — | — | 1 | 6.00 |
| CHEMBL4109308 | — | — | 1 | 5.92 |
| CHEMBL4130157 | — | — | 1 | 5.85 |
| CHEMBL4128388 | — | — | 1 | 5.54 |
| CHEMBL4126072 | — | — | 1 | 4.71 |
| CHEMBL4127311 | — | — | 1 | 4.52 |
| CHEMBL4127458 | — | — | 1 | 4.36 |
| CHEMBL4128250 | — | — | 1 | - |
| CHEMBL4127016 | — | — | 1 | - |
| CHEMBL3952343 | — | — | 1 | - |
| CHEMBL4114159 | — | — | 1 | - |
| CHEMBL4108338 | — | — | 1 | - |
| CHEMBL4107559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126496 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4109308 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4130157 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4128388 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4126072 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4127311 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL4127458 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL4128250 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4127016 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3952343 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4114159 | — | IC50 | > | 19700.0 | nM | - |
| CHEMBL4108338 | — | IC50 | > | 12700.0 | nM | - |
| CHEMBL4107559 | — | IC50 | >= | 20000.0 | nM | - |