Assay Detail
Functional
CHEMBL5036252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured for 72 hrs by cell titer glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biaryl Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 10.53 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085549 | — | — | 1 | 10.70 |
| CHEMBL5077700 | — | — | 1 | 10.70 |
| CHEMBL5083643 | — | — | 1 | 10.52 |
| CHEMBL5075013 | — | — | 1 | 10.52 |
| CHEMBL5073905 | — | — | 1 | 10.52 |
| CHEMBL5092899 | — | — | 1 | 10.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085549 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL5077700 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL5083643 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL5075013 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL5073905 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL5092899 | — | IC50 | = | 0.06 | nM | 10.22 |