Assay Detail
Functional
CHEMBL5036868
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Cytotoxicity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.30 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5088760 | — | — | 1 | 4.74 |
| CHEMBL5071369 | — | — | 1 | 4.55 |
| CHEMBL5091647 | — | — | 1 | 4.46 |
| CHEMBL5091334 | — | — | 1 | 4.36 |
| CHEMBL5092483 | — | — | 1 | 4.33 |
| CHEMBL5089457 | — | — | 1 | 4.32 |
| CHEMBL5083185 | — | — | 1 | 4.30 |
| CHEMBL5086342 | — | — | 1 | 4.30 |
| CHEMBL5089459 | — | — | 1 | 4.29 |
| CHEMBL5091900 | — | — | 1 | 4.25 |
| CHEMBL5084565 | — | — | 1 | 4.25 |
| CHEMBL5079142 | — | — | 1 | 4.13 |
| CHEMBL5083742 | — | — | 1 | 4.12 |
| CHEMBL5092006 | — | — | 1 | 4.07 |
| CHEMBL5073147 | — | — | 1 | 4.05 |
| CHEMBL5085162 | — | — | 1 | - |
| CHEMBL5091798 | — | — | 1 | - |
| CHEMBL5083481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5088760 | — | IC50 | = | 18390.0 | nM | 4.74 |
| CHEMBL5071369 | — | IC50 | = | 28450.0 | nM | 4.55 |
| CHEMBL5091647 | — | IC50 | = | 34840.0 | nM | 4.46 |
| CHEMBL5091334 | — | IC50 | = | 43250.0 | nM | 4.36 |
| CHEMBL5092483 | — | IC50 | = | 47060.0 | nM | 4.33 |
| CHEMBL5089457 | — | IC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL5083185 | — | IC50 | = | 50390.0 | nM | 4.30 |
| CHEMBL5086342 | — | IC50 | = | 50280.0 | nM | 4.30 |
| CHEMBL5089459 | — | IC50 | = | 51280.0 | nM | 4.29 |
| CHEMBL5091900 | — | IC50 | = | 56250.0 | nM | 4.25 |
| CHEMBL5084565 | — | IC50 | = | 56340.0 | nM | 4.25 |
| CHEMBL5079142 | — | IC50 | = | 74050.0 | nM | 4.13 |
| CHEMBL5083742 | — | IC50 | = | 75530.0 | nM | 4.12 |
| CHEMBL5092006 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL5073147 | — | IC50 | = | 89560.0 | nM | 4.05 |
| CHEMBL5085162 | — | IC50 | = | 659350.0 | nM | - |
| CHEMBL5091798 | — | IC50 | = | 581360.0 | nM | - |
| CHEMBL5083481 | — | IC50 | = | 837050.0 | nM | - |