Assay Detail
Functional
CHEMBL5037035
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Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 3 days by CellTiter-Glo assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.10 | 8.82 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094191 | — | — | 1 | 8.82 |
| CHEMBL5084741 | — | — | 1 | 7.28 |
| CHEMBL4742712 | — | — | 1 | 7.21 |
| CHEMBL5069911 | — | — | 1 | 7.05 |
| CHEMBL5073414 | — | — | 1 | 5.13 |
| CHEMBL5078971 | — | — | 1 | - |
| CHEMBL5084281 | — | — | 1 | - |
| CHEMBL5079426 | — | — | 1 | - |
| CHEMBL5078004 | — | — | 1 | - |
| CHEMBL5090015 | — | — | 1 | - |
| CHEMBL5074427 | — | — | 1 | - |
| CHEMBL4170596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094191 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5084741 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4742712 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5069911 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5073414 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5078971 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5084281 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5079426 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5078004 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5090015 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5074427 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4170596 | — | Activity | - | — | - |