Compound Detail
CHEMBL5084281
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Basic Information
| ChEMBL ID | CHEMBL5084281 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WVKNOEMSHFZOMC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
461.9
MW (Da)
1.85
ALogP
6
HBA
2
HBD
129.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon/DNA damage-binding protein 1 CHEMBL4630734 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon/DNA damage-binding protein 1 | IC50 | = | 1.0 | nM | 9.0 | Displacement of Cy5-O-Len probe from 6XHis-tagged CRBN/DDB1 (unknown origin) inc... | 34042448 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34042448 | 10.1021/acs.jmedchem.0c01313 | MV4-11 | 1 |
| 34042448 | 10.1021/acs.jmedchem.0c01313 | Protein cereblon/GSPT1 | 1 |
| 34042448 | 10.1021/acs.jmedchem.0c01313 | No relevant target | 1 |
| 34042448 | 10.1021/acs.jmedchem.0c01313 | ADMET | 1 |
| 34042448 | 10.1021/acs.jmedchem.0c01313 | Protein cereblon/DNA damage-binding protein 1 | 1 |
Data from ChEMBL 36 via Core Engine