Assay Detail
Functional
CHEMBL5037439
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Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth in presence of fetal calf serum incubated for 96 hrs measured by celltiter-glo luminescent cell viability assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.12 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5087022 | — | — | 1 | 7.54 |
| CHEMBL4589249 | — | — | 1 | 7.38 |
| CHEMBL5075021 | — | — | 1 | 7.10 |
| CHEMBL3962241 | — | — | 1 | 7.07 |
| CHEMBL4286578 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5087022 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4589249 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5075021 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3962241 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4286578 | — | IC50 | = | 310.0 | nM | 6.51 |