Assay Detail
ADMET
CHEMBL5038525
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Inhibition of recombinant human hepatic CYP1A2 expressed in baculovirus insect cell expression system in presence of CEC substrate measured by fluorescence plate reader assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.06 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5072213 | — | — | 1 | 7.00 |
| CHEMBL5075517 | — | — | 1 | 6.70 |
| CHEMBL5072152 | — | — | 1 | 6.52 |
| CHEMBL5074659 | — | — | 1 | 6.30 |
| CHEMBL5089676 | — | — | 1 | 5.68 |
| CHEMBL5082744 | — | — | 1 | 5.35 |
| CHEMBL5091256 | — | — | 1 | 4.88 |
| CHEMBL5087053 | — | — | 1 | - |
| CHEMBL5092554 | — | — | 1 | - |
| CHEMBL5081532 | — | — | 1 | - |
| CHEMBL5089702 | — | — | 1 | - |
| CHEMBL5091051 | — | — | 1 | - |
| CHEMBL5072616 | — | — | 1 | - |
| CHEMBL5091818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5072213 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5075517 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5072152 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5074659 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5089676 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5082744 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5091256 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5087053 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5092554 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5081532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5089702 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091051 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5072616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091818 | — | IC50 | > | 50000.0 | nM | - |