Assay Detail
Binding
CHEMBL5039183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DPCPX from human A1 receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A<sub>2A</sub> Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.10 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124345 | — | — | 1 | 8.52 |
| CHEMBL5093654 | — | — | 1 | 7.16 |
| CHEMBL5078507 | — | — | 1 | 7.07 |
| CHEMBL5093743 | — | — | 1 | 6.95 |
| CHEMBL5091876 | — | — | 1 | 6.54 |
| CHEMBL5088305 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124345 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL5093654 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL5078507 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL5093743 | — | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL5091876 | — | Ki | = | 288.4 | nM | 6.54 |
| CHEMBL5088305 | — | Ki | = | 416.87 | nM | 6.38 |