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Assay Detail

CHEMBL5039231

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Human enterovirus 71 BrCr infected in human RD cells assessed as reduction in virus-induced cytopathic effect incubated for 4 days by MTS/PMS assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Enterovirus A71
Cell Type RD
Confidence 1 — Organism
Curated By Autocuration

Target

Enterovirus A71 (CHEMBL612436)
Type ORGANISM
Organism Enterovirus A71

Publication

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.
Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H.
J Med Chem (2022) 65 : 2794 -2808
PubMed 33872498 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 6.72 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20636 1 7.96
CHEMBL5076204 1 7.52
CHEMBL5069521 1 7.37
CHEMBL5082778 1 7.16
CHEMBL5094273 1 7.05
CHEMBL5092841 1 7.03
CHEMBL5090935 1 7.03
CHEMBL5087722 1 7.02
CHEMBL477147 1 7.00
CHEMBL5093941 1 6.92
CHEMBL5086301 1 6.92
CHEMBL5094426 1 6.85
CHEMBL5087004 1 6.66
CHEMBL5092077 1 6.54
CHEMBL5080519 1 6.52
CHEMBL5073563 1 6.50
CHEMBL5079072 1 6.44
CHEMBL5084942 1 6.43
CHEMBL5094984 1 6.36
CHEMBL5079443 1 6.33
CHEMBL5086024 1 6.16
CHEMBL5078067 1 6.11
CHEMBL5085665 1 5.92
CHEMBL5086209 1 5.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20636 EC50 = 11.0 nM 7.96
CHEMBL5076204 EC50 = 30.0 nM 7.52
CHEMBL5069521 EC50 = 43.0 nM 7.37
CHEMBL5082778 EC50 = 70.0 nM 7.16
CHEMBL5094273 EC50 = 90.0 nM 7.05
CHEMBL5092841 EC50 = 93.0 nM 7.03
CHEMBL5090935 EC50 = 94.0 nM 7.03
CHEMBL5087722 EC50 = 96.0 nM 7.02
CHEMBL477147 EC50 = 100.0 nM 7.00
CHEMBL5093941 EC50 = 120.0 nM 6.92
CHEMBL5086301 EC50 = 120.0 nM 6.92
CHEMBL5094426 EC50 = 140.0 nM 6.85
CHEMBL5087004 EC50 = 220.0 nM 6.66
CHEMBL5092077 EC50 = 290.0 nM 6.54
CHEMBL5080519 EC50 = 300.0 nM 6.52
CHEMBL5073563 EC50 = 320.0 nM 6.50
CHEMBL5079072 EC50 = 360.0 nM 6.44
CHEMBL5084942 EC50 = 370.0 nM 6.43
CHEMBL5094984 EC50 = 440.0 nM 6.36
CHEMBL5079443 EC50 = 470.0 nM 6.33
CHEMBL5086024 EC50 = 690.0 nM 6.16
CHEMBL5078067 EC50 = 770.0 nM 6.11
CHEMBL5085665 EC50 = 1210.0 nM 5.92
CHEMBL5086209 EC50 = 3100.0 nM 5.51