Assay Detail
Functional
CHEMBL5039280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV 1 25710-2 subtype C assessed as inhibition of viral entry preincubated for 30 min followed by U87-CD4-CRC5 positive cells addition and culture medium replacement after 12 hrs post infection and measured after 48 hrs by luciferase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.24 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 7.94 |
| CHEMBL5078598 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL5078598 | — | IC50 | = | 298.0 | nM | 6.53 |