Assay Detail
Functional
CHEMBL5039282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 IIIB assessed as inhibition of HIV-1 Env mediated cell-cell fusion in MT-2 cells preincubated for 30 mins followed by cell addition and measured after 2 hrs by calcein AM staining based fluorescence microscopy
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.98 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 7.62 |
| CHEMBL5078598 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5078598 | — | IC50 | = | 472.0 | nM | 6.33 |