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Assay Detail

CHEMBL5039778

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Binding
Binding affinity to 5-HT1ER (unknown origin)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1E (CHEMBL2182)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of G Protein-Biased Ligands against 5-HT<sub>7</sub>R.
Lee J, Kwag R, Lee S, Kim D, Woo J, Cho Y, Kim HJ, Kim J, Jeon B, Choo H.
J Med Chem (2021) 64 : 7453 -7467
PubMed 34032427 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.71 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5091373 1 6.75
CHEMBL5077293 1 6.11
CHEMBL5074190 1 5.66
CHEMBL3961059 1 5.62
CHEMBL5094234 1 5.58
CHEMBL3931889 1 5.39
CHEMBL5083607 1 5.39
CHEMBL5084249 1 5.17
CHEMBL5074880 1 -
CHEMBL5081379 1 -
CHEMBL5094680 1 -
CHEMBL5071978 1 -
CHEMBL5082177 1 -
CHEMBL5093342 1 -
CHEMBL5090884 1 -
CHEMBL5094493 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5091373 Ki = 180.0 nM 6.75
CHEMBL5077293 Ki = 770.0 nM 6.11
CHEMBL5074190 Ki = 2200.0 nM 5.66
CHEMBL3961059 Ki = 2400.0 nM 5.62
CHEMBL5094234 Ki = 2600.0 nM 5.58
CHEMBL3931889 Ki = 4100.0 nM 5.39
CHEMBL5083607 Ki = 4100.0 nM 5.39
CHEMBL5084249 Ki = 6700.0 nM 5.17
CHEMBL5074880 Ki > 10000.0 nM -
CHEMBL5081379 Ki > 10000.0 nM -
CHEMBL5094680 Ki > 10000.0 nM -
CHEMBL5071978 Ki > 10000.0 nM -
CHEMBL5082177 Ki > 10000.0 nM -
CHEMBL5093342 Ki > 10000.0 nM -
CHEMBL5090884 Ki > 10000.0 nM -
CHEMBL5094493 Ki > 10000.0 nM -