Assay Detail
Binding
CHEMBL5040534
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Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 33 | 6.34 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5087695 | — | — | 1 | 8.00 |
| CHEMBL5074716 | — | — | 1 | 7.40 |
| CHEMBL2063787 | — | — | 1 | 7.22 |
| CHEMBL5088083 | — | — | 1 | 7.16 |
| CHEMBL5092684 | — | — | 1 | 7.00 |
| CHEMBL5086296 | — | — | 1 | 6.85 |
| CHEMBL5075163 | — | — | 1 | 6.85 |
| CHEMBL5072207 | — | — | 1 | 6.82 |
| CHEMBL5075837 | — | — | 1 | 6.75 |
| CHEMBL5085623 | — | — | 1 | 6.60 |
| CHEMBL5080710 | — | — | 1 | 6.50 |
| CHEMBL5084363 | — | — | 1 | 6.42 |
| CHEMBL5078735 | — | — | 1 | 6.40 |
| CHEMBL5092932 | — | — | 1 | 6.38 |
| CHEMBL5069753 | — | — | 1 | 6.31 |
| CHEMBL5070762 | — | — | 1 | 6.19 |
| CHEMBL5082879 | — | — | 1 | 6.16 |
| CHEMBL5081194 | — | — | 1 | 5.95 |
| CHEMBL5090223 | — | — | 1 | 5.74 |
| CHEMBL5085898 | — | — | 1 | 5.56 |
| CHEMBL5076196 | — | — | 1 | 5.45 |
| CHEMBL5093510 | — | — | 1 | 5.39 |
| CHEMBL5082005 | — | — | 1 | 5.31 |
| CHEMBL5071009 | — | — | 1 | 5.18 |
| CHEMBL57267 | — | — | 1 | 4.82 |
| CHEMBL5092397 | — | — | 1 | - |
| CHEMBL5091796 | — | — | 1 | - |
| CHEMBL5094700 | — | — | 1 | - |
| CHEMBL5079958 | — | — | 1 | - |
| CHEMBL5082659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5087695 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL5074716 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL2063787 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL5088083 | — | Kd | = | 70.0 | nM | 7.16 |
| CHEMBL5092684 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL5086296 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL5075163 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL5072207 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL5075837 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL5085623 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL5080710 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL5084363 | — | Kd | = | 380.0 | nM | 6.42 |
| CHEMBL5078735 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL5092932 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL5069753 | — | Kd | = | 490.0 | nM | 6.31 |
| CHEMBL5070762 | — | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL5082879 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL5081194 | — | Kd | = | 1130.0 | nM | 5.95 |
| CHEMBL5090223 | — | Kd | = | 1830.0 | nM | 5.74 |
| CHEMBL5085898 | — | Kd | = | 2740.0 | nM | 5.56 |
| CHEMBL5076196 | — | Kd | = | 3580.0 | nM | 5.45 |
| CHEMBL5093510 | — | Kd | = | 4050.0 | nM | 5.39 |
| CHEMBL5082005 | — | Kd | = | 4880.0 | nM | 5.31 |
| CHEMBL5071009 | — | Kd | = | 6660.0 | nM | 5.18 |
| CHEMBL57267 | — | Kd | = | 15200.0 | nM | 4.82 |
| CHEMBL5092397 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5091796 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5094700 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5079958 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5082659 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5086126 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5091351 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5082010 | — | Kd | > | 10000.0 | nM | - |