Assay Detail
Binding
CHEMBL5041012
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Inhibition of Escherichia coli DNA gyrase supercoiling activity using pBR322 as substrate incubated for 30 mins by fluorimetric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.71 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090088 | — | — | 1 | 6.37 |
| CHEMBL5086095 | — | — | 1 | 6.26 |
| CHEMBL5084320 | — | — | 1 | 6.11 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.08 |
| CHEMBL5086519 | — | — | 1 | 6.05 |
| CHEMBL5092701 | — | — | 1 | 5.96 |
| CHEMBL5075535 | — | — | 1 | 5.91 |
| CHEMBL5087299 | — | — | 1 | 5.90 |
| CHEMBL5089465 | — | — | 1 | 5.88 |
| CHEMBL5085647 | — | — | 1 | 5.88 |
| CHEMBL5087899 | — | — | 1 | 5.84 |
| CHEMBL5084570 | — | — | 1 | 5.71 |
| CHEMBL5093987 | — | — | 1 | 5.70 |
| CHEMBL5078898 | — | — | 1 | 5.54 |
| CHEMBL5092628 | — | — | 1 | 5.45 |
| CHEMBL5076830 | — | — | 1 | 5.25 |
| CHEMBL5090251 | — | — | 1 | 5.23 |
| CHEMBL5076468 | — | — | 1 | 5.20 |
| CHEMBL5080786 | — | — | 1 | 4.89 |
| CHEMBL5072607 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090088 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5086095 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5084320 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5086519 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5092701 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5075535 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5087299 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5089465 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5085647 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL5087899 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL5084570 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5093987 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL5078898 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL5092628 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5076830 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL5090251 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL5076468 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL5080786 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5072607 | — | IC50 | = | 12800.0 | nM | 4.89 |