Assay Detail
Functional
CHEMBL5041223
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Antinociceptive activity against Sprague-Dawley rat model of thermal stimuli induced nociception assessed as concentration required for maximal tail flick withdrawal latency administered subcutaneously as single dose measured up to 24 hrs by tail flick test
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na<sub>v</sub>1.7 for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.16 | 6.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085021 | — | — | 1 | 6.53 |
| CHEMBL5076349 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085021 | — | EC50 | = | 294.0 | nM | 6.53 |
| CHEMBL5076349 | — | EC50 | = | 1619.0 | nM | 5.79 |