Assay Detail
Binding
CHEMBL5041445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel protein 2 (CHEMBL2547) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K<sub>Ca</sub>2 Channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 5.34 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086997 | — | — | 1 | 6.19 |
| CHEMBL5078247 | — | — | 1 | 6.00 |
| CHEMBL5074700 | — | — | 1 | 5.72 |
| CHEMBL5076878 | — | — | 1 | 5.70 |
| CHEMBL5076032 | — | — | 1 | 5.53 |
| CHEMBL5081906 | — | — | 1 | 5.49 |
| CHEMBL5075016 | — | — | 1 | 5.46 |
| CHEMBL5077913 | — | — | 1 | 5.45 |
| CHEMBL5094656 | — | — | 1 | 5.37 |
| CHEMBL5079766 | — | — | 1 | 5.35 |
| CHEMBL5082158 | — | — | 1 | 5.30 |
| CHEMBL5088936 | — | — | 1 | 5.18 |
| CHEMBL453730 | — | — | 1 | 5.13 |
| CHEMBL5094693 | — | — | 1 | 4.86 |
| CHEMBL5088498 | — | — | 1 | 4.41 |
| CHEMBL5074647 | — | — | 1 | 4.30 |
| CHEMBL5072517 | — | — | 1 | - |
| CHEMBL5088379 | — | — | 1 | - |
| CHEMBL5079837 | — | — | 1 | - |
| CHEMBL5086120 | — | — | 1 | - |
| CHEMBL5090801 | — | — | 1 | - |
| CHEMBL5076140 | — | — | 1 | - |
| CHEMBL5090420 | — | — | 1 | - |
| CHEMBL5079951 | — | — | 1 | - |
| CHEMBL5075803 | — | — | 1 | - |
| CHEMBL5084004 | — | — | 1 | - |
| CHEMBL5075501 | — | — | 1 | - |
| CHEMBL5084258 | — | — | 1 | - |
| CHEMBL5090455 | — | — | 1 | - |
| CHEMBL5093708 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086997 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5078247 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5074700 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL5076878 | — | EC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL5076032 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5081906 | — | EC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL5075016 | — | EC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL5077913 | — | EC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL5094656 | — | EC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL5079766 | — | EC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL5082158 | — | EC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL5088936 | — | EC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL453730 | — | EC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL5094693 | — | EC50 | = | 13770.0 | nM | 4.86 |
| CHEMBL5088498 | — | EC50 | = | 38810.0 | nM | 4.41 |
| CHEMBL5074647 | — | EC50 | = | 49720.0 | nM | 4.30 |
| CHEMBL5069418 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5079218 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5088689 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5089976 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5081876 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5083279 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5080805 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5093708 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5090455 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5084258 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5075501 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5084004 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5075803 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5079951 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5090420 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5076140 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5090801 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5086120 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5079837 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5088379 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5072517 | — | EC50 | > | 100000.0 | nM | - |