Compound Detail
CHEMBL5074647
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Basic Information
| ChEMBL ID | CHEMBL5074647 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCFTVJNDYDYVRA-GASCZTMLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
315.4
MW (Da)
2.96
ALogP
6
HBA
1
HBD
64.9
PSA (Ų)
0.94
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 2 CHEMBL2547 | EC50 | 4.3 | 4.3 | 49720.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 2 | EC50 | = | 49720.0 | nM | 4.3 | Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potentia... | 34962403 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34962403 | 10.1021/acs.jmedchem.1c01473 | Small conductance calcium-activated potassium channel protein 2 | 2 |
Data from ChEMBL 36 via Core Engine