Assay Detail
Functional
CHEMBL5041536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| IC50 | 2 | 7.35 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594350 | ADAGRASIB | 4.0 | 1 | 8.40 |
| CHEMBL5086956 | — | — | 1 | 6.29 |
| CHEMBL5094756 | — | — | 1 | - |
| CHEMBL5089479 | — | — | 1 | - |
| CHEMBL5091525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594350 | ADAGRASIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5086956 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL5094756 | — | Activity | - | — | - | |
| CHEMBL5089479 | — | Activity | - | — | - | |
| CHEMBL5091525 | — | Activity | - | — | - |