Assay Detail
Binding
CHEMBL5041730
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Inhibition of human amyloid beta (1 to 42) in human SKNBE2 cells expressing wild-type amyloid precursor protein hAPP695 incubated for 18 hrs by sandwich ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SKNBE2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5084378 | — | — | 1 | 9.00 |
| CHEMBL5093303 | — | — | 1 | 9.00 |
| CHEMBL5082406 | — | — | 1 | 8.92 |
| CHEMBL5074068 | — | — | 1 | 8.89 |
| CHEMBL5077699 | — | — | 1 | 8.60 |
| CHEMBL5085412 | — | — | 1 | 8.59 |
| CHEMBL2152899 | — | — | 1 | 8.48 |
| CHEMBL5075933 | — | — | 1 | 8.44 |
| CHEMBL5093195 | — | — | 1 | 8.32 |
| CHEMBL5073381 | — | — | 1 | 8.20 |
| CHEMBL5085521 | — | — | 1 | 8.07 |
| CHEMBL5088449 | — | — | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5084378 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5093303 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5082406 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5074068 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5077699 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5085412 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2152899 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5075933 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5093195 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5073381 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5085521 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5088449 | — | IC50 | = | 12.6 | nM | 7.90 |