Assay Detail
Binding
CHEMBL5042029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.56 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL212710 | — | — | 1 | 8.05 |
| CHEMBL5077796 | — | — | 1 | 7.46 |
| CHEMBL5075705 | — | — | 1 | 7.00 |
| CHEMBL5075686 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL212710 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL5077796 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL5075705 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5075686 | — | Ki | = | 440.0 | nM | 6.36 |